货号：E-2024057752
CAS：1443421-69-9
规格：mg(更多包装需求请咨询客服)
纯度：95%+
生产商：试剂家

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Catalogue Number:A105035
Chemical Name:Abacavir 5’-4-Chloro-6-methylpyrimidine-2,5-diamine
Synonyms:N6-Cyclopropyl-9-((1R,4S)-4-(((2,5-diamino-6-chloropyrimidin-4-yl)oxy)methyl)cyclopent-2-en-1-yl)-9H-purine-2,6-diamine; Abacavir USP Related Compound D; Abacavir EP Impurity B; ; Abacavir Impurities;Abacavir EP Impurity B / USP - D
Impurity:Abacavir EP Impurity B
CAS Number:1443421-69-9
Molecular Formula:C₁₈H₂₁ClN₁₀O
Molecular Weight:428.88
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Abacavir 5’-4-Chloro-6-methylpyrimidine-2,5-diamine (Abacavir EP Impurity B) is a degradation product of Abacavir Sulfate (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
References:(1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012)
(2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)
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