货号：E-2024057829
CAS：1420477-60-6
规格：mg(更多包装需求请咨询客服)
纯度：95%+
生产商：试剂家

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Catalogue Number:A115605
Chemical Name:Acalabrutinib
Synonyms:4-[8-amino-3-[(2S)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl]-N-2-pyridinylbenzamide; ACP 196
CAS Number:1420477-60-6
Molecular Formula:C₂₆H₂₃N₇O₂
Appearance:Pale Yellow to Pale Beige Solid
Melting Point:>133°C (dec.)
Molecular Weight:465.51
Storage:4°C
Solubility:DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Acalabrutinib, is an experimental anti-cancer drug and a selective Bruton's tyrosine kinase (BTK) inhibitor. This kinase transmits signals from B-cell Receptor (BCR), and thus any genetic BTK mutation causes B-Cell immunodeficiency. Therefore, BTK inhibitors targeting B-cell signaling has shown great promise for the treatment of chronic lymphocytic leukemia (CLL).
References:'Byrd; et al. (2015). ''Acalabrutinib (ACP-196) in Relapsed Chronic Lymphocytic Leukemia.''; ''AstraZeneca to buy Acerta for blood cancer drug''. www.rsc.org. Chemistry World - Royal Society of Chemistry. Retrieved 24 December 2015.'
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