货号：E-2024057921
CAS：167838-64-4
规格：mg(更多包装需求请咨询客服)
纯度：95%+
生产商：试剂家

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Catalogue Number:A133025
Chemical Name:3-[6-(Acetylamino)-3-pyridinyl]-N-[2-[[2,4-dichloro-3-[[(2-methyl-8-quinolinyl)oxy]methyl]phenyl]methylamino]-2-oxoethyl]-(E)-2-propenamide
Synonyms:FR 173657;(2E)-3-[6-(Acetylamino)-3-pyridinyl]-N-[2-[[2,4-dichloro-3-[[(2-methyl-8-quinolinyl)oxy]methyl]phenyl]methylamino]-2-oxoethyl]-2-propenamide;(2E)-3-[6-(Acetylamino)-3-pyridinyl]-N-[2-[[2,4-dichloro-3-[[(2-methyl-8-quinolinyl)oxy]methyl]phenyl]methylamino]-2-oxoethyl]-2-propenamide;(E)-3-(4-Acetamidophenyl)-N-(2-((2,4-dichloro-3-(((2-methylquinolin-8-yl)oxy)methyl)phenyl)(methyl)amino)-2-oxoethyl)acrylamide
CAS Number:167838-64-4
Molecular Formula:C₃₁H₂₈Cl₂N₄O₄
Molecular Weight:591.48
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:3-[6-(Acetylamino)-3-pyridinyl]-N-[2-[[2,4-dichloro-3-[[(2-methyl-8-quinolinyl)oxy]methyl]phenyl]methylamino]-2-oxoethyl]-(E)-2-propenamide, or FR 173657, is a nonpeptide bradyykinin B2 receptor antagonist. It is an orally-active noncompetitive antagonist with high affinity to the B2, that inhibits BK-induced bronchoconstriction and B2 receptor-mediated phosphatidylinositol hydrolysis
References:Asano, M., et. al.: Br. J. Pharmacol., 120, 617 (1997);Aramori, I., et. al.: Mol. Pharmacol., 51, 171 (1997)
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