货号：E-2024064247
CAS：939431-68-2
规格：mg(更多包装需求请咨询客服)
纯度：95%+
生产商：试剂家

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Catalogue Number:A939460
Chemical Name:4-[[6-Amino-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3,5-dimethylbenzonitrile
Synonyms:Amino CPP Dimethylbenzonitrile Impurity; Des-bromo Etravirine;
CAS Number:939431-68-2
Molecular Formula:C₂₀H₁₆N₆O
Melting Point:284.5-287 °C
Molecular Weight:356.38
Category:Building Blocks; Miscellaneous; Enzyme Activators and Inhibitors; Anti-virals/Anti-retrovirals;
Boiling Point
632.1±65.0 °C
Applications:4-[[6-Amino-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3,5-dimethylbenzonitrile is an impurity of Etravirine (E937000), which is a novel HIV reverse transcriptase inhibitor useful in treatment of HIV infection. It can be used as a novel HIV-1 NNRTIs by using its hydrophobic channel and tolerant regions of NNIBP. It can also be used to synthesize etravirine, a non-nucleoside reverse transcriptase inhibitor.
References:Kang, D., et.al., Eur.J.Med.Chem., 193, 112237, (2020); Maikap, G.S., et.al., Indian, 19, (2016); Scholler-Gyure, M., et al.: J. Clin. Pharmacol., 48, 322 (2008), Thakur, A., et al.: Eur. J. Med. Chem., 43, 471 (2008),
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