Cy5 Picolyl Azide|Cyanine5 Picolyl Azide
   
Cy5 Picolyl Azide is an advanced fluorescent probe that incorporates a copper-chelating motif to raise the effective concentration of Cu(I) at the reaction site. The chelating effect of picolyl azide moiety to raise the effective concentration of copper at the reaction site is so great that it leads to an increase of signal intensity of up to 40-fold.
In addition, the use of Cy5 Picolyl Azide instead of conventional Cy5-Azide allows for at least a tenfold reduction in the concentration of the copper catalyst without sacrificing the efficiency of labeling.
In summary, the introduction of a picolyl moiety into an azide probe leads to a substantial increase in the sensitivity of alkyne detection. This will be of special value for the detection of low abundance targets or where significant increase in signal intensity is desired.
structural formula：
    
Cy5 Picolyl Azide|Cyanine5 Picolyl Azide
Abs/Em Maxima
647/663 nm
Extinction coefficient
250,000
Flow cytometry laser line
633 or 635 nm
Microscopy laser line
633 or 635 nm
Spectrally similar dyes
Alexa Fluor® 647, Atto™ 647, CF™ 647 Dye, DyLight™649
Molecular weight
953.15
CAS
N/A
Solubility
Water, DMSO, DMF, MeOH
Purity
>95% (HPLC)
Appearance
Blue solid
Storage conditions
-20C
Shipping conditions
Ambient temperature
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TAMRA alkyne, 5-isomer
 
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Sulfo-Cyanine5.5 alkyne
 
磺酸基-Cy5 炔烃 Sulfo-Cyanine5 alkyne
 
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3-Ethynyl perylene
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Pyrene azide 3
 
Pyrene azide 2
 
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Perylene azide
 
PEP azide
 
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