生物活性：Glyburide-d11 is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
试剂家 has not independently confirmed the accuracy of these methods. They are for reference only.
Glyburide-d11 相关抗体:
Parkin Antibody
MCU Antibody
ATP1A1 Antibody
Calumenin Antibody (YA813)
Mitofusin 2 Antibody
P Glycoprotein Antibody
LIAS Antibody
NDUFS8 Antibody (YA1352)
TOMM20 Antibody (YA1380)
NUDT9 Antibody (YA1453)
MRP1 Antibody (YA1583)
CPS1 Antibody (YA1661)
Complex III Subunit 5 Antibody (YA1865)
NDUFB8 Antibody (YA1947)
MFF Antibody (YA2012)
NDUFS4 Antibody (YA2072)
MT ND1 Antibody (YA2089)
Mitochondrial Fission 1 Protein Antibody (YA2098)
Cyclophilin 40 Antibody (YA2099)
TIMM44 Antibody (YA2207)
NDUFS1 Antibody (YA2535)
CLPX Antibody (YA2814)
LGI1 Antibody (YA2885)
MTCO2 Antibody (YA3254)
Mitochondrial Ferritin Antibody (YA3353)
mtTFA Antibody (YA3360)
Mitofusin 1 Antibody
MRP4 Antibody (YA1166)
Ornithine Carbamoyltransferase/OTC Antibody (YA1230)
NDUFB10 Antibody (YA1330)
分子量：505.07
Formula：C23H17D11ClN3O5S
CAS 号：1189985-02-1
非标记 CAS：10238-21-8
中文名称：格列本脲 d11
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (533 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
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[2]. Heo R, et al. The anti-diabetic drug trelagliptin induces vasodilation via activation of Kv channels and SERCA pumps. Life Sci. 2021;283:119868.
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[3]. Qiu Y, et al. Glyburide Regulates UCP1 Expression in Adipocytes Independent of KATP Channel Blockade. iScience. 2020;23(9):101446.
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[4]. Golstein PE, et al. P-glycoprotein inhibition by glibenclamide and related compounds. Pflugers Arch. 1999;437(5):652-660.
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[5]. Fernandes MA, et al. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability. J Biochem Mol Toxicol. 2004;18(3):162-169.
 [Content Brief]
[6]. Zhou J, et al. Glibenclamide-Induced Autophagy Inhibits Its Insulin Secretion-Improving Function in β Cells. Int J Endocrinol. 2019;2019:1265175.
 [Content Brief]