Name:Cirtuvivint
Synonyms:SM08502
CAS Number:2143917-62-6
Formula:C24H25N7O
M.w.:427.5
DMSO (mg/mL)Max Solubility:22
DMSO (mM)Max Solubility:51.46
Form:free base
SMILES:CN1CCN(CC1)C2=CC(=CC=N2)C(=O)NC3=CC4=C(C=CC(=C4)C5=C[N](C)N=C5)C=N3
ALogP:2.587
Target:CDK
Pathway:Cell Cycle
Information:Cirtuvivint (SM08502) is a potent and orally active inhibitor of CDC-like kinase (CLK) and a DYRK (dual-specificity tyrosine kinase) that targets mRNA splicing and is optimized for Wnt pathway inhibition. Cirtuvivint inhibits serine and arginine-rich splicing factor (SRSF) phosphorylation and disrupts spliceosome activity. Cirtuvivint can be used for solid tumor research.
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