Name:ENMD-2076
Synonyms:N/A
CAS Number:934353-76-1
Formula:C21H25N7
M.w.:375.47
DMSO (mg/mL)Max Solubility:105
DMSO (mM)Max Solubility:279.65
Form:Tartaric Acid
SMILES:CN1CCN(CC1)C2=CC(=NC(=N2)\C=C\C3=CC=CC=C3)NC4=N[NH]C(=C4)C
ALogP:4.015
Target:Apoptosis related,Aurora Kinase,CSF-1R,FGFR,FLT3,PDGFR,Src,VEGFR
Pathway:Angiogenesis
Information:ENMD-2076 has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold selective for Aurora A than over Aurora B and less potent to RET, SRC, NTRK1/TRKA, CSF1R/FMS, VEGFR2/KDR, FGFR and PDGFRα. ENMD-2076 inhibits the growth of a wide range of human solid tumor and hematopoietic cancer cell lines with IC50 from 0.025 to 0.7 μM, which induces apoptosis and G2/M phase arrest. Phase 2.
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