Name:Posaconazole (SCH 56592)
Synonyms:SCH 56592,POS,Noxafil
CAS Number:171228-49-2
Formula:C37H42F2N8O4
M.w.:700.78
DMSO (mg/mL)Max Solubility:100
DMSO (mM)Max Solubility:142.7
Form:free base
SMILES:CCC(C(C)O)N1N=CN(C1=O)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(OCC5COC(C5)(C[N]6C=NC=N6)C7=CC=C(F)C=C7F)C=C4
ALogP:5.096
Target:P450 (e.g. CYP17)
Pathway:Metabolism
Information:Posaconazole (SCH 56592,POS,Noxafil) is an inhibitor primarily of CYP3A4, but it does not inhibit the activity of other CYP enzymes; Also an inhibitor of sterol C14ɑ demethylase inhibitor with IC50 of 0.25 μM. Posaconazole has a median terminal elimination half-life of 15-35 hours.
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