Name:Laduviglusib (CHIR-99021)
Synonyms:CT99021
CAS Number:252917-06-9
Formula:C22H18Cl2N8
M.w.:465.34
DMSO (mg/mL)Max Solubility:10
DMSO (mM)Max Solubility:21.49
Form:free base
SMILES:CC1=C[NH]C(=N1)C2=CN=C(NCCNC3=CC=C(C=N3)C#N)N=C2C4=CC=C(Cl)C=C4Cl
ALogP:4.476
Target:Autophagy,GSK-3,Wnt/beta-catenin
Pathway:PI3K/Akt/mTOR
Information:Laduviglusib (CHIR-99021, CT99021) is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively. CHIR99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) and shows a 350-fold selectivity toward GSK-3β compared to CDKs. CHIR99021 functions as a Wnt/β-catenin activator and induces autophagy.
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