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CAS:556813-39-9|CHIR-98014
- 产品货号：E-2024050429
- 发布时间：2024-05-21
- 产品CAS ：556813-39-9
- 产品规格：mg(更多包装需求请咨询客服)
- 产品纯度：95%+
- 产品货期：现货下单后48小时内发货，定制产品4-8周。
- 运输条件：顺丰常规运输
产品详情
货号：E-2024050429
CAS：556813-39-9
规格：mg(更多包装需求请咨询客服)
纯度：95%+
生产商：试剂家
试剂家(www.empireagents.com) - 瑞禧生物旗下试剂品牌。致力于为全球客户提供高性价比的助力药物递送的产品服务。公司的奋斗目标是搭建一个国际知名的药物递送修饰平台，携手高端人才和所有合作伙伴，共同为人类各行各业的事业发展做出贡献！
Catalogue Number:C292100
Chemical Name:CHIR-98014
Synonyms:N6-[2-[[4-(2,4-Dichlorophenyl)-5-(1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]-3-nitro-
CAS Number:556813-39-9
Molecular Formula:C₂₀H₁₇Cl₂N₉O₂
Appearance:Yellow Solid
Melting Point:192-196°C (dec.)
Molecular Weight:486.31
Storage:4°C
Solubility:DMSO, Methanol
Category:Research Tools; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:A glycogen synthase kinase-3 (GSK-3) inhibitor. Effects of GSK inhibitors on p-tau, GSK-3b activities and cell death were measured in a human neuronal cell line (LUHMES). Lithium and CHIR98014 reduced tau phosphorylation (Ser396) in the cortex and hippocampus. Inhibition of GSK-3 is recently regarded as one of the viable approaches to therapy for Alzheimer's disease, cancer, diabetes mellitus, osteoporosis, and bipolar mood disorder.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References:Aardema, M., et al.: Mutat. Res., 410, 3试剂家(www.empireagents.com)从未停止过技术的拓展与创新。凭借这充满进取的创新精神，我们已经为国内外高校、科研单位、材料研究中心、生物技术制药开发公司等等定制合成了各种功能化试剂，赢得了合作单位的长期信赖。
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