货号：E-2024050800
CAS：1384516-10-2
规格：mg(更多包装需求请咨询客服)
纯度：95%+
生产商：试剂家

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Catalogue Number:C364235
Chemical Name:N-(4-Chlorobenzyl)-1-(5-nitrothiophen-2-yl)methanamine
CAS Number:1384516-10-2
Molecular Formula:C₁₂H₁₁ClN₂O₂S
Appearance:Light Brown to Brown Solid
Melting Point:>41°C (dec.)
Molecular Weight:282.75
Storage:-20°C, Inert atmosphere
Solubility:Chloroform (Slightly), DMSO (Slightly)
Category:Building Blocks;
Applications:N-(4-Chlorobenzyl)-1-(5-nitrothiophen-2-yl)methanamine is an analogue of GSK 4112 (G797700) which is a synthetic ligand for REV-ERBa, a member of the nuclear receptor superfamily that functions as a receptor for the porphoryin heme. GSK 4112 mimics the action of heme acting as agonist and suppresses the expression of REV-ERBa target genes involved in gluconeogenesis.
References:Kojetin, D., et al.: ACS Chem. Biol., 6, 131 (2011); Grant, D., et al.: ACS Chem. Biol., 5, 925 (2010)
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