货号：E-2024050825
CAS：1568-36-1
规格：mg(更多包装需求请咨询客服)
纯度：95%+
生产商：试剂家

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Catalogue Number:C364395
Chemical Name:1-(3-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid Methyl Ester
Synonyms:1-(m-Chlorobenzoyl)-5-methoxy-2-methyl-indole-3-acetic Acid Methyl Ester
CAS Number:1568-36-1
Molecular Formula:C₂₀H₁₈ClNO₄
Appearance:Pale Yellow Solid
Melting Point:113-115°C
Molecular Weight:371.81
Storage:-20°C
Solubility:Chloroform (Slightly), Methanol (Very Slightly, Heated)
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:1-(3-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid Methyl Ester is an intermediate used to prepare 4-Dechloro-3-chloroindomethacin (D226245), an impurity of Indomethacin (I641000) which inhibits cyclooxygenase (IC50=0.1uM) selectively over liposygenases (IC50=100uM for 5-,12- and 15-LO).
References:Salari, H., et al.: Prostagland. Leukotrienes Med., 13, 53 (1984), Lehmann, J.M., et al.: J. Biol. Chem., 272, 3406 (1997)
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