货号：E-2024051095
CAS：1809817-93-3
规格：mg(更多包装需求请咨询客服)
纯度：95%+
生产商：试剂家

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Catalogue Number:C365703
Chemical Name:N-​[Chloro(4-​nitrophenoxy)​phosphinyl]​-L-​alanine 1-​Methylethyl Ester
CAS Number:1809817-93-3
Molecular Formula:C₁₂H₁₆ClN₂O₆P
Molecular Weight:350.69
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:N-​[Chloro(4-​nitrophenoxy)​phosphinyl]​-L-​alanine 1-​Methylethyl Ester is an intermediate in synthesizing PSI-7977-D5 (P839643), an isotope labelled analog of PSI-7977. PSI-7977 is a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
References:Lam, A.M.,et al.: Antimicrob. Agents. Chemotherapy., 56, 3359 (2012); Lam, A.M., et al.: J. Virol., 85, 12334 (2011); Sofia, M.J., et al.: J. Medn. Chem., 53, 7202 (2010)
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