货号：E-2024051299
CAS：75802-84-5
规格：mg(更多包装需求请咨询客服)
纯度：95%+
生产商：试剂家

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Catalogue Number:C366940
Chemical Name:4-Chloro Kynurenine
Synonyms:α,2-Diamino-4-chloro-γ-oxobenzenebutanoic Acid; (+/-)-α,2-Diamino-4-chloro-γ-oxobenzenebutanoic Acid; 4-Cl-KYN; (+/-)-AV-101;
CAS Number:75802-84-5
Molecular Formula:C₁₀H₁₁ClN₂O₃
Appearance:Off-White to Yellow Solid
Melting Point:>165°C (dec.)
Molecular Weight:242.66
Storage:4°C
Solubility:Aqueous Acid (Slightly), DMSO (Sparingly)
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:7-Cl-kynurenic acid (7-Cl-KYNA) is a potent, selective antagonist of the NMDA/glycine receptor but penetrates poorly through the blood-brain barrier.  Its prodrug, L-4-Cl-kynurenine (4-Cl-KYN), readily enters the brain from the circulation and provides antiexcitotoxic neuroprotection after systemic application.
References:Leeson, P., et al.: J. Med. Chem., 37, 4053 (1994), Hilmas, C., et al.: J. Neurosci., 2001, 21, 7463 (2001), Palmer, G., et al.: Curr. Drug Targets, 2, 241 (2001), Wu, H., et al.: Exp. Neurol., 177, 222 (2002),
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