货号：E-2024051881
CAS：22978-25-2
规格：mg(更多包装需求请咨询客服)
纯度：95%+
生产商：试剂家

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Catalogue Number:C374050
Chemical Name:2-Chloro-5-nitro-N-4-phenylbenzamide
Synonyms:GW9662
CAS Number:22978-25-2
Molecular Formula:C₁₃H₉ClN₂O₃
Appearance:White to Off-White Solid
Melting Point:157-159°C
Molecular Weight:276.68
Storage:4°C
Solubility:DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
Category:Building Blocks; Miscellaneous;
Applications:A cell-permeable, selective and irreversible PPARγ antagonist (IC50 = 3.3 nM, 32 nM, and 2 uM for PPARγ, PPARa, and PPARδ, respectively). Reported to covalently modify a cysteine residue in the binding site of PPAR. At a concentration of 10 uM, also acts as an agonist of human pregnane X receptor (PXR) and farnesoid X receptor (FXR). Does not activate liver X receptor-a (LXRa), retinoic acid receptor (RAR), retinoid X receptor-a (RXRa) and thyroid receptors a and b (TRa and TRb
References:Huang, J.T., et al.: Nature, 400, 378 (1999), Wilson, T.M., et al.: J. Med. Chem., 43, 527 (2000), Leesnitzer, L.M., et al.: Biochemistry, 41, 6640 (2002)
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