货号：E-2024053214
CAS：937606-68-3
规格：mg(更多包装需求请咨询客服)
纯度：95%+
生产商：试剂家

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Catalogue Number:C453520
Chemical Name:1-Chloroacetyloxindole
Synonyms:1-(2-Chloroacetyl)-1,3-dihydro-2H-indol-2-one;1-(2-Chloroacetyl)-2,3-dihydro-1H-indol-2-one
CAS Number:937606-68-3
Molecular Formula:C₁₀H₈ClNO₂
Molecular Weight:209.63
Category:Building Blocks; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:1-Chloroacetyloxindole is an intermediate in the synthesis of N-[4-[[(Z)-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)phenylmethyl]amino]phenyl]-N,4-dimethyl-1-piperazineacetamide (D452513), used in the study to discover a potent inhibitor of MELK that inhibits expression of the anti-apoptotic protein Mcl-1 and TNBC cell growth. N-[4-[[(Z)-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)phenylmethyl]amino]phenyl]-N,4-dimethyl-1-piperazineacetamide is an impurity of Intedanib (I666650), which is an antitumor agent.
References:Edupuganti, R., et al.: Bioorg. Med. Chem., 25, 2609 (2017); Sun, L., et al.: J. Med. Chem., 41, 2588 (1998); Xie, H., et al.: J. Med. Chem., 50, 4898 (2007); Hilberg, F., et al.: Cancer Res., 68, 4774 (2008); Roth, G., et al.: J. Med. Chem., 58, 1053 (2015)
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