货号：E-2024053438
CAS：154226-60-5
规格：mg(更多包装需求请咨询客服)
纯度：95%+
生产商：试剂家

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Catalogue Number:C562500
Chemical Name:Clasto-lactacystin(Omuralide)
Synonyms:(1R,4R,5S)-1-[(1S)-1-Hydroxy-2-methylpropyl]-4-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione; Clasto-lactacystin β-Lactone; Omuralide
CAS Number:154226-60-5
Molecular Formula:C₁₀H₁₅NO₄
Appearance:White Solid
Melting Point:186-187°C
Molecular Weight:213.23
Storage:-20°C
Solubility:DMF, Ethanol, Hot Ethyl Acetate, Methanol, Pyridine
Category:Standards; Enzyme Activators and Inhibitors;
Applications:A cell permeable, irreversible proteasome inhibitor. It is 20-fold more potent than Lactacystin. Lactacytstin spontaneously converts to clasto-lactacystin in biological systems. Clasto-lactacystin is the only cell permeable form of lactacystin. Induces neurite growth and inhibits cell cycle progression similar to lactacytin.
References:Craiu, A., et al.: J. Biol. Chem., 272, 13437 (1997), Dick, G.L.R., et al.: J. Biol. Chem., 272, 182 (1997), Fenteany, G. and Schreiber, S.: J. Biol. Chem., 273, 8545 (1998), Corey, E.J., et al.: J.A.C.S., 120, 2330 (1998)
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