货号：E-2024055353
CAS：1460272-53-0
规格：mg(更多包装需求请咨询客服)
纯度：95%+
生产商：试剂家

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Catalogue Number:C992278
Chemical Name:4-((3-(4-(Cyclopropanecarbonyl)piperazine-1-carbonyl)-4-fluorophenyl)(hydroxy)methyl)phthalazin-1(2H)-one
Synonyms:Olaparib Metabolite M15
CAS Number:1460272-53-0
Molecular Formula:C₂₄H₂₃FN₄O₄
Appearance:White to Off-White Solid
Melting Point:234 - 238°C
Molecular Weight:450.46
Storage:-20°C, Inert atmosphere
Solubility:DMSO (Slightly), Methanol (Slightly, Sonicated)
Category:Research Tools; Molecular Biology; Enzyme Activators and Inhibitors;
Applications:4-((3-(4-(Cyclopropanecarbonyl)piperazine-1-carbonyl)-4-fluorophenyl)(hydroxy)methyl)phthalazin-1(2H)-one is an impurity of Olaparib (O514500), a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Olaparib has been shown to induce significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo. Recent studies show that Olaparib increases radiosensitivity of a lung tumor xenograft, making it a potential candidate for use in combination with radiotherapy. Potent PARP inhibitor.
References:Weston, V.J. et al.: Blood, 116, 4578 (2010); Senra, J.M. et al.: Mol. Cancer Therap., 10, 1949 (2011); Schaefer, N.G. et al.: Nuc. Med. Comm., 32, 1046 (2011);
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