货号：E-2024055610
CAS：1423119-98-5
规格：mg(更多包装需求请咨询客服)
纯度：95%+
生产商：试剂家

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Catalogue Number:D101002
Chemical Name:Dabrafenib-d9
Synonyms:N-[3-[5-(2-Amino-4-pyrimidinyl)-2-[1,1-di(methyl-d3)ethyl-2,2,2-d3]-4-thiazolyl]-2-fluorophenyl]-2,6-difluoro-benzenesulfonamide; GSK 2118436-d9; Tafinlar-d9
CAS Number:1423119-98-5
Alternate CAS #
Unlabelled: 1195765-45-7
Molecular Formula:C₂₃H₁₁D₉F₃N₅O₂S₂
Appearance:White to Off-White Solid
Melting Point:221-223°C (dec.)
Molecular Weight:528.62
Storage:-20°C
Solubility:DMF (Slightly), DMSO (Slightly)
Category:Research Tools;
Applications:Dabrafenib-d9 is the isotope labelled analog of Dabrafenib (D101000); an inhibitor of mutated BRAF kinase. Dabrafenib also has clinical activity with a manageable safety profile in clinical trials of phase 1 and 2 in patients with BRAF(V600)-mutated metastatic melanoma.
References:Hauschild, A., et al.: Lancet, 380, 358 (2012); Falchook, G.S., et al.: Lancet, 379, 1893 (2012); Ascierto, P.A., et al.: J. Clin. Oncol., 31, 3205 (2013)
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