货号：E-2024055611
CAS：1195768-06-9
规格：mg(更多包装需求请咨询客服)
纯度：95%+
生产商：试剂家

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Catalogue Number:D101005
Chemical Name:Dabrafenib Mesylate
Synonyms:GSK 2118436 Methanesulfonate Salt; GSK 2118436B; N-[3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluoro-benzenesulfonamide Methanesulfonate
CAS Number:1195768-06-9
Alternate CAS #
1195765-45-7 free amine
Molecular Formula:C₂₄H₂₄F₃N₅O₅S₃
Appearance:White to Off-White Solid
Melting Point:>234ºC (dec.)
Molecular Weight:615.67
Storage:-20°C, Hygroscopic
Solubility:DMSO (Slightly, Heated), Methanol (Slightly)
Stability
Hygroscopic
Category:Standards; Enzyme Activators and Inhibitors;
Applications:Dabrafenib is an inhibitor of mutated BRAF kinase and has clinical activity with a manageable safety profile in clinical trials of phase 1 and 2 in patients with BRAF(V600)-mutated metastatic melanoma.
References:Hauschild, A., et al.: Lancet, 380, 358 (2012); Falchook, G.S., et al.: Lancet, 379, 1893 (2012); Ascierto, P.A., et al.: J. Clin. Oncol., 31, 3205 (2013)
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