货号：E-2024057030
CAS：1393526-40-3
规格：mg(更多包装需求请咨询客服)
纯度：95%+
生产商：试剂家

试剂家(www.empireagents.com) - 瑞禧生物旗下试剂品牌。致力于为全球客户提供高性价比的助力药物递送的产品服务。公司的奋斗目标是搭建一个国际知名的药物递送修饰平台，携手高端人才和所有合作伙伴，共同为人类各行各业的事业发展做出贡献！
Catalogue Number:D233020
Chemical Name:(2'R)-2'-Deoxy-3',5'-bis-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-fluoro-2'-methyl-uridine
CAS Number:1393526-40-3
Molecular Formula:C₂₂H₄₁FN₂O₅Si₂
Appearance:Pale Yellow Oil
Molecular Weight:488.74
Solubility:Chloroform, Dichloromethane, Ethyl Acetate, Methanol
Category:Standards; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:(2'R)-2'-Deoxy-3',5'-bis-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-fluoro-2'-methyl-uridine is an intermediate in the synthesis of Sofosbuvir (R)-Phosphate (S675615), which is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-a-fluoro-b-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
References:Lam, A.M.,et al.: Antimicrob. Agents. Chemotherapy., 56, 3359 (2012); Lam, A.M., et al.: J. Virol., 85, 12334 (2011); Sofia, M.J., et al.: J. Medn. Chem., 53, 7202 (2010)
试剂家(www.empireagents.com)从未停止过技术的拓展与创新。凭借这充满进取的创新精神，我们已经为国内外高校、科研单位、材料研究中心、生物技术制药开发公司等等定制合成了各种功能化试剂，赢得了合作单位的长期信赖。
更多产品推荐:
CAS:1189650-18-7|rac Demethyl Citalopram-d3 Hydrochloride
CAS:149732-51-4|Demethyl Curcumin
CAS:1188264-72-3|rac Desmethyl Citalopram Hydrobromide
CAS:102491-80-5|2-Demethyl Colchicine
CAS:7336-33-6|3-Demethyl Colchicine
CAS:1314417-96-3|3-Demethyl Colchicine-d3
CAS:52744-22-6|4-Demethyl Daunomycinone
CAS:5241-24-7|Demethyldihydrolanosterol
CAS:1202160-36-8|(R)-N-Demethyl Dapoxetine
CAS:147199-39-1|(S)-N-Demethyl Dapoxetine