货号：E-2024057032
CAS：1256490-54-6
规格：mg(更多包装需求请咨询客服)
纯度：95%+
生产商：试剂家

试剂家(www.empireagents.com) - 瑞禧生物旗下试剂品牌。致力于为全球客户提供高性价比的助力药物递送的产品服务。公司的奋斗目标是搭建一个国际知名的药物递送修饰平台，携手高端人才和所有合作伙伴，共同为人类各行各业的事业发展做出贡献！
Catalogue Number:D233030
Chemical Name:N-[[P(S),2'R]-2'-deoxy-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-L-alanine 1-Methylethyl Ester
CAS Number:1256490-54-6
Molecular Formula:C₂₈H₄₃FN₃O₉PSi
Appearance:White Solid
Molecular Weight:643.71
Solubility:Chloroform, Dichloromethane, Methanol
Category:Standards; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:N-[[P(S),2'R]-2'-deoxy-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-L-alanine 1-Methylethyl Ester is an intermediate in the synthesis of Sofosbuvir (R)-Phosphate (S675615), which is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-a-fluoro-b-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
References:Lam, A.M.,et al.: Antimicrob. Agents. Chemotherapy., 56, 3359 (2012); Lam, A.M., et al.: J. Virol., 85, 12334 (2011); Sofia, M.J., et al.: J. Medn. Chem., 53, 7202 (2010)
试剂家(www.empireagents.com)从未停止过技术的拓展与创新。凭借这充满进取的创新精神，我们已经为国内外高校、科研单位、材料研究中心、生物技术制药开发公司等等定制合成了各种功能化试剂，赢得了合作单位的长期信赖。
更多产品推荐:
CAS:1346604-45-2|rac-N-Demethyl Dimethindene-d3 Hydrobromide
CAS:913079-71-7|3-Demethyl Colchicine 3-O-β-D-Glucuronide
CAS:3590-93-0|4'-Demethyldesoxypodophyllotoxin
CAS:6559-91-7|4'-Demethylepipodophyllotoxin
CAS:21253-58-7|4-Demethyltrimethoprim
CAS:639460-79-0|N-Demethyl-N-formylolanzapine
CAS:67372-69-4|6,7-Demethylene-6,7-dehydro Drospirenone
CAS:2125720-11-6|N-Demethyl-3,4-dihydroxytamoxifen Hydrochloride(Z,E mixture)
CAS:67372-68-3|6,7-Demethylene Drospirenone
CAS:81149-12-4|(5'a,10a)-1-Demethyl-9,10-dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)-2,3(2H,3H)-secoergotaman-3,3',6',18-tetrone