货号：E-2024057477
CAS：149709-44-4
规格：mg(更多包装需求请咨询客服)
纯度：95%+
生产商：试剂家

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Catalogue Number:D288245
Chemical Name:Desethyl Sacubitril
Synonyms:[S-(R*,S*)]-γ-[(3-Carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-Biphenyl]-4-pentanoic Acid; (2R,4S)-4-[(3-Carboxy-1-oxopropyl)amino]-4-[(p-phenylphenyl)methyl]-2-methylbutanoic Acid; (2R,4S)-5-(Biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2-methylpentanoic Acid; Sacubitrilat; LBQ 657
CAS Number:149709-44-4
Molecular Formula:C₂₂H₂₅NO₅
Appearance:White to Off-White Solid
Melting Point:166-168°C
Molecular Weight:383.44
Storage:4°C
Solubility:DMSO (Slightly), Methanol (Slightly)
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Desethyl Sacubitril is an impurity in the synthesis of Sacubitril (S080895), an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.
References:McMurray, J., et al.: N. Eng. J. Med., 371 (2014);
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