货号：E-2024059551
CAS：850140-73-7
规格：mg(更多包装需求请咨询客服)
纯度：95%+
生产商：试剂家

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Catalogue Number:A355315
Chemical Name:Afatinib Dimaleate
Synonyms:BIBW 2992MA2; (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide (2Z)-2-butenedioate;
CAS Number:850140-73-7
Alternate CAS #
Free Base: 439081-18-2 [B377000]
Molecular Formula:C₂₄H₂₅ClFN₅O₃•[C₄H₄O₄]₂
Appearance:White to Pale Yellow Solid
Melting Point:>237ºC (dec.)
Molecular Weight:718.1
Storage:4°C
Solubility:DMSO (Slightly), Methanol (Slightly)
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Afatinib Dimaleate is a salt of Afatinib {BIBW 2992) (B377000), an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder. An anilino-quinazoline that irreversibly inhibits EGFR and HER2 kinase activity.
References:D, Li. et al.: Oncogene., 27, 4702 (2008); Wang, X. et al.: Cancer Res., 74, 4431 (2014);
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