货号：E-2024059679
CAS：134036-52-5
规格：mg(更多包装需求请咨询客服)
纯度：95%+
生产商：试剂家

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Catalogue Number:A425000
Chemical Name:AG-490
Synonyms:2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide; Tyrphostin B 42;
CAS Number:134036-52-5
Molecular Formula:C₁₇H₁₄N₂O₃
Appearance:Yellow to Dark Yellow Solid
Melting Point:>213°C (dec.)
Molecular Weight:294.3
Storage:-20°C
Solubility:Acetone, Chloroform (Slightly, Sonicated), DMSO (Slightly), Ethanol, Methanol
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:A potent and specific inhibitor of the Jak-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. AG-490 is cell permeable and is active in vivo.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References:Stock, J., et al.: J. Biol. Chem., 267, 19753
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