CAS:149690-12-0|(2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride_小分子定制_常见产品

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CAS:149690-12-0|(2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride

产品货号：E-2024060594
发布时间：2024-06-07
产品CAS ：149690-12-0
产品规格：mg(更多包装需求请咨询客服)
产品纯度：95%+
产品货期：现货下单后48小时内发货，定制产品4-8周。
运输条件：顺丰常规运输

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货号：E-2024060594
CAS：149690-12-0
规格：mg(更多包装需求请咨询客服)
纯度：95%+
生产商：试剂家

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Catalogue Number:A601540
Chemical Name:(2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride
Synonyms:(αR,γS)-γ-Amino-α-methyl-[1,1'-biphenyl]-4-pentanoic Acid Ethyl Ester Hydrochloride; [S-(R*,S*)]-γ-Amino-α-methyl-[1,1'-biphenyl]-4-pentanoic Acid Ethyl Ester Hydrochloride; Ethyl (2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-amino-2-methylpentanoate Hydrochloride
CAS Number:149690-12-0
Alternate CAS #
Free base: 752174-62-2
Molecular Formula:C₂₀H₂₅NO₂ • HCl
Appearance:White to Off-White Solid
Melting Point:155 - 162°C
Molecular Weight:347.88 + (36.46)
Storage:-20°C
Solubility:DMSO (Slightly), Methanol (Slightly)
Stability
Hygroscopic
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites; Phenethylamines/Amphetamines;
Applications:(2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride is used as a reagent in the synthesis of LCZ696, an angiotensin II receptor and neprilysin receptor dual inhibitor. (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride is also used as a reagent in the preparation of novel NEP inhibitor prodrugs for the treatment of hypertension and cardiovascular diseases.
References:Liu, M., et al.: Faming Zhuanli Shenqing. CN 105168205 A 20151223. Dec 23, 2015; Wang, Z.: PCT Int. Appl. WO 2015154673 A1 20151015. Oct 15, 2015
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