货号：E-2024063486
CAS：108605-62-5
规格：mg(更多包装需求请咨询客服)
纯度：95%+
生产商：试剂家

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Catalogue Number:A771720
Chemical Name:A77 1726 (E/Z) Mixture
Synonyms:2-Cyano-3-hydroxy-N-(4-trifluoromethylphenyl)crotonamide; 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide; rac-Teriflunomide; USP Leflunomide Related Compound B;
Impurity:Leflunomide USP Related Compound B
CAS Number:108605-62-5
Molecular Formula:C₁₂H₉F₃N₂O₂
Appearance:White to Off-White Solid
Melting Point:228-230°C (dec.)
Molecular Weight:270.21
Storage:-20°C, Inert atmosphere, Light sensitive
Solubility:DMSO (Slightly), Methanol (Sparingly)
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:rac A77 1726 is the active metabolite of Leflunomide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. LEF-M interferes with dendritic cell function. The second Phase III study evaluating the efficacy of Genzyme’s teriflunomide therapy against relapsing forms of multiple sclerosis found the once-daily oral drug to be no less effective than injectable interferon beta 1a (Rebif®). Leflunomide USP Related Compound B.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References:Kirsch, B.M., et al.: Arthritis Research and Therapy, 7, 3, R694, (2005)
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