货号：DX20251019028
CAS：1787294-07-8
规格：100mg，500mg，可根据需求定制。
纯度：98%+
生产商：试剂家

Name:Remibrutinib (LOU064)
Synonyms:N/A
CAS Number:1787294-07-8
Formula:C27H27F2N5O3
M.w.:507.53
DMSO (mg/mL)Max Solubility:100
DMSO (mM)Max Solubility:197.03
Form:free base
SMILES:CN(CCOC1=C(N=CN=C1N)C2=C(C)C(=CC(=C2)F)NC(=O)C3=C(F)C=C(C=C3)C4CC4)C(=O)C=C
ALogP:4.374
Target:BTK,Interleukins
Pathway:Angiogenesis
Information:Remibrutinib (LOU064) is a potent, highly selective covalent inhibitor of bruton tyrosine kinase (BTK) with IC50 of 1.3 nM, 2.5 nM and 18 nM for BTK, FcγR-induced IL8 and anti-IgM/IL4-induced CD69, respectively. Remibrutinib (LOU064) exhibits an exquisite kinase selectivity due to binding to an inactive conformation of BTK and has the potential for the treatment of autoimmune diseases.
试剂家是您专业的小分子合成定制合作伙伴。我们专注于为医药研发、材料科学及学术研究提供从毫克到公斤级的一站式合成解决方案。无论是常规分子、复杂手性化合物、同位素标记物还是特定杂质，我们的资深团队都能凭借先进技术平台高效完成。我们始终坚持严格的质量控制，确保产品纯度与结构准确，并恪守保密承诺。选择试剂家，就是选择可靠与精准，让我们以***的合成能力，加速您的创新突破。欢迎垂询，定制您的专属分子。