货号：DX20251019037
CAS：237430-03-4
规格：100mg，500mg，可根据需求定制。
纯度：98%+
生产商：试剂家

Name:Alsterpaullone
Synonyms:Alp, 9-Nitropaullone, NSC 705701
CAS Number:237430-03-4
Formula:C16H11N3O3
M.w.:293.28
DMSO (mg/mL)Max Solubility:25
DMSO (mM)Max Solubility:85.24
Form:Free Base
SMILES:[O-][N+](=O)C1=CC2=C([NH]C3=C2CC(=O)NC4=CC=CC=C34)C=C1
ALogP:2.817
Target:Apoptosis related,Caspase,CDK,GSK-3
Pathway:Cell Cycle
Information:Alsterpaullone (Alp, 9-Nitropaullone, NSC 705701) is a potent inhibitor of CDK with IC50 of 35 nM, 15 nM, 200 nM and 40 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p35, respectively. Alsterpaullone also acts as a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with IC50 of both 4 nM for GSK-3α and GSK-3β. Alsterpaullone induces apoptosis by activation of caspase-9. Alsterpaullone has antitumor activity and possesses potential for the treatment of neurodegenerative and proliferative disorders.
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