货号：DX20251020080
CAS：154447-36-6
规格：100mg，500mg，可根据需求定制。
纯度：98%+
生产商：试剂家

Name:LY294002
Synonyms:SF 1101, NSC 697286
CAS Number:154447-36-6
Formula:C19H17NO3
M.w.:307.34
DMSO (mg/mL)Max Solubility:36
DMSO (mM)Max Solubility:117.13
Form:free base
SMILES:O=C1C=C(OC2=C(C=CC=C12)C3=CC=CC=C3)N4CCOCC4
ALogP:3.342
Target:Apoptosis related,Autophagy,Casein Kinase,DNA-PK,PI3K
Pathway:PI3K/Akt/mTOR
Information:LY294002 (SF 1101, NSC 697286) is the first synthetic molecule known to inhibit PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM, respectively; more stable in solution than Wortmannin, and also blocks autophagosome formation. It not only binds to class I PI3Ks and other PI3K-related kinases, but also to novel targets seemingly unrelated to the PI3K family. LY294002 also inhibits CK2 with IC50 of 98 nM. LY294002 is a non-specific DNA-PKcs inhibitor and activates autophagy and apoptosis.
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