货号：E-2024056429
CAS：2244245-33-6
规格：mg(更多包装需求请咨询客服)
纯度：95%+
生产商：试剂家

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Catalogue Number:D228230
Chemical Name:Defluoro O-Methyl Dolutegravir
Synonyms:(4R,12aS)-N-(4-Fluorobenzyl)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
CAS Number:2244245-33-6
Molecular Formula:C₂₁H₂₂FN₃O₅
Molecular Weight:415.42
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Defluoro O-Methyl Dolutegravir is an intermediate in the synthesis of Defluoro Dolutegravir (D228715) which is an impurity of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.
References:Kobayashi, M. et al. Antimicrob Agents Chemother., 55, 813 (2011); Garrido, C. et al.: Antiviral, Res., 90, 164 (2011); Lenz, J.C.C. et al.: Exp. Opin. Invest. Drugs, 20, 537 (2011);
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