货号：E-2024056462
CAS：915087-16-0
规格：mg(更多包装需求请咨询客服)
纯度：95%+
生产商：试剂家

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Catalogue Number:D228590
Chemical Name:Defluoro-MDV 3100 (Defluoro-enzalutamide)
Synonyms:4-[3-[4-Cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-N-methylbenzamide; 4-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]-N-methylbenzamide;
CAS Number:915087-16-0
Molecular Formula:C₂₁H₁₇F₃N₄O₂S
Appearance:Pale Yellow to Light Yellow Solid
Melting Point:>206°C (dec.)
Molecular Weight:446.45
Storage:4°C
Solubility:Acetone (Slightly), Chloroform (Slightly)
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Defluoro-MDV 3100 (Defluoro-enzalutamide) is an impurity of Enzalutamide (M199800), which is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. Enzalutamide has been shown to induce tumor cell apoptosis, and is used for the treatment of castration-resistant prostate cancer.
References:Scher, H.I. et al.: Lancet, 375, 1437 (2010); Bellmunt, J. et al.: Ther. Adv. Med. Oncol., 2, 189 (2010); Ryan, C.J. et al.: J. Clin. Oncol., 29, 3651 (2011); Ma, X., et al.: J. Pharm. Biomed. Anal., 131, 436 (2016);
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