货号：E-2024061421
CAS：155750-92-8
规格：mg(更多包装需求请咨询客服)
纯度：95%+
生产商：试剂家

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Catalogue Number:A611155
Chemical Name:(1R,2S,4R)-4-Amino-2-hydroxy-cyclopentanemethanol Hydrochloride
Synonyms:[1R-(1α,2β,4α)]-4-Amino-2-hydroxy-cyclopentanemethanol Hydrochloride
CAS Number:155750-92-8
Molecular Formula:C₆H₁₃NO₂•HCl
Molecular Weight:131.17+(36.46)
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:(1R,2S,4R)-4-Amino-2-hydroxy-cyclopentanemethanol Hydrochloride can be used as a reagent/reactant for stereoselective synthesis and antiviral activity of carbocyclic nucleoside analog of pentylphenylfuropyrimidine deoxyribose via stereoselective hydroboration, heterocyclization and Sonogashira coupling from Vince lactam (1). (1R,2S,4R)-4-Amino-2-hydroxy-cyclopentanemethanol Hydrochloride can also be obtained from (1R)-(-)-2-Azabicyclo[2.2.1]hept-5-en-3-one (A795205) which is an Abacavir intermediate used in the synthesis of carbocyclic sugar amines, carbanucleosides, and carbocyclic dinucleotide analogues (2).
References:(1) Migilore, M. D., et al.: J. Med. Chem. 50, 6485-6492 (2007)
(2) Slama, J.T., et al.: Biochemistry 27, 183 (1988)
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