货号：E-2024062116
CAS：545380-34-5
规格：mg(更多包装需求请咨询客服)
纯度：95%+
生产商：试剂家

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Catalogue Number:A621350
Chemical Name:6-Amino-4-(4-phenoxyphenylethylamino)quinazoline
Synonyms:N4-[2-(4-Phenoxyphenyl)ethyl]-4,6-quinazolinediamine; QNZ;
CAS Number:545380-34-5
Molecular Formula:C₂₂H₂₀N₄O
Appearance:Light Beige to Dark Yellow Solid
Melting Point:>170°C (dec.)
Molecular Weight:356.42
Storage:4°C
Solubility:DMSO (Slightly), Methanol (Slightly, Heated)
Category:Standards; Enzyme Activators and Inhibitors;
Applications:QNZ is a novel inhibitor of NFkB which displays potent inhibitory effects on both NFKB transcriptional activation (IC50=11nM) and TNF-a production (IC50=7nM). It dose-dependently inhibited carragenin-induced edema formation in the rat paw model (1mg/Kg). A useful tool to explore the role of NFkB in cellular signaling pathways.
References:Tobe, M., et al.: Bioorg. Med. Chem., 11, 3869 (2003), Choi, S., et al.: J. Biol. Chem., 281, 12722 (2006)
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