货号：E-2024063315
CAS：172822-28-5
规格：mg(更多包装需求请咨询客服)
纯度：95%+
生产商：试剂家

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Catalogue Number:A729770
Chemical Name:(2S,3S,1’R)-Aprepitant
Synonyms:[2S-[2α(S*),3β]]-5-[[2-[1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one
CAS Number:172822-28-5
Molecular Formula:C₂₃H₂₁F₇N₄O₃
Molecular Weight:534.43
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:(2S,3S,1’R)-Aprepitant is an impurity of Aprepitant (A729800); a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic. (2S,3S,1’R)-Aprepitant is also a useful synthetic intermediate in the synthesis of morpholine tachykinin receptor antagonist prodrugs.
References:Hale, J.J., et al.: J. Med. Chem., 41, 4607 (1998); Campos, D., et al.: J. Clin. Oncol., 19, 1759 (2001); Van Belle, S., et al.: Cancer, 94, 3032 (2002); Majumdar, A.K., et al.: J. Clin. Pharmacol., 46, 291 (2006); Gangula, S., et al.: Synthetic Commun., 40, 2254 (2010); Dorn, C.P., et al.: PCT Int. Appl. WO 9523798 A1 19950908. Sep 8, 1995
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