货号：DX20251020688
CAS：633-65-8
规格：100mg，500mg，可根据需求定制。
纯度：98%+
生产商：试剂家

Name:Berberine chloride (NSC 646666)
Synonyms:Natural Yellow 18 chloride
CAS Number:633-65-8
Formula:C20H18NO4.Cl
M.w.:371.81
DMSO (mg/mL)Max Solubility:40
DMSO (mM)Max Solubility:107.58
Form:chloride
SMILES:[Cl-].COC1=CC=C2C=C3C4=C(CC[N+]3=CC2=C1OC)C=C5OCOC5=C4
ALogP:1.289
Target:Anti-infection,Apoptosis related,Autophagy,Bcl-2,Caspase,IAP,JNK,p38 MAPK,P450 (e.g. CYP17),PARP,ROS,Topoisomerase
Pathway:Microbiology
Information:Berberine chloride (NSC 646666, Natural Yellow 18) is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. Berberine chloride decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. Berberine chloride induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. Berberine chloride is a dual topoisomerase I and II inhibitor. Berberine chloride is also a potential autophagy modulator.
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