货号：E-T202508210001
CAS：N/A
规格：mg
纯度：≥95%
生产商：试剂家

生物活性：Navtemadlin-d7 is the deuterium labeled Navtemadlin. Navtemadlin (AMG 232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction, with an IC50 of 0.6 nM. Navtemadlin binds to MDM2 with a Kd of 0.045 nM[1][2].
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
试剂家 has not independently confirmed the accuracy of these methods. They are for reference only.
Navtemadlin-d7 相关抗体:
p53 Antibody
p53 Antibody (YA250)
SUMO1 Antibody (YA046)
p27 KIP 1 Antibody
Ubiquitin Antibody (YA022)
Ubiquitin D Antibody
p21 Antibody (YA254)
p21 Antibody
FOXO4 Antibody
p53 (acetyl K382) Antibody
p53 DINP1 Antibody
p53 (acetyl K370)Antibody
Phospho-p53 (Ser392) Antibody
Acetyl-p53 (Lys370) Antibody
Phospho-p53 (Ser37) Antibody
Phospho-p53 (Ser6) Antibody
SUMO1 Antibody (YA047)
TRIM21 Antibody (YA658)
Ubiquitin Antibody
Phospho-CBL (Tyr774) Antibody (YA1014)
Phospho-Rb2 p130 (Ser952) Antibody (YA1034)
SUMO2/3 Antibody (YA1048)
SUMO2/3 Antibody (YA1049)
TBL1XR1 Antibody (YA1053)
SKP2 Antibody (YA1332)
RNF8 Antibody (YA1344)
UFM1 Antibody (YA1577)
PERP Antibody (YA1674)
COPS8 Antibody (YA1679)
SAE1 Antibody (YA1847)
分子量：575.60
Formula：C28H28D7Cl2NO5S
非标记 CAS：1352066-68-2
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (533 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
 [Content Brief]
[2]. Canon J, et al. The MDM2 Inhibitor AMG 232 Demonstrates Robust Antitumor Efficacy and Potentiates the Activity of p53-Inducing Cytotoxic Agents. Mol Cancer Ther. 2015 Mar;14(3):649-58.
 [Content Brief]
[3]. Rew Y, et al. Discovery of a small molecule MDM2 inhibitor (AMG 232) for treating cancer. J Med Chem. 2014 Aug 14;57(15):6332-41.
 [Content Brief]