货号：E-T202508210001
CAS：N/A
规格：mg
纯度：≥95%
生产商：试剂家

生物活性：Fenoprofen-13C6 (LILLY-53858-13C6) sodium hydrate is the 13C labeled Fenoprofen (HY-B1456A).Fenoprofen (LILLY-53858) is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits cyclooxygenase (COX). Fenoprofen is a melanocortin receptors (MCRs) positive allosteric modulator (PAM). Fenoprofen also increases ERK1/2 activation in HEK293T cells. Fenoprofen has anti-arthritic activities and can be used for the study of rheumatoid arthritis and osteoarthritis[1][2][3].
体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注。
试剂家 has not independently confirmed the accuracy of these methods. They are for reference only.
Fenoprofen-13C6 sodium hydrate 相关抗体:
ERK1/2 Antibody
Phospho-ERK1/2 (Thr202/Tyr204)/(Thr185/Tyr187) Antibody
Phospho-ERK1/2 (Thr202/Tyr204)/(Thr185/Tyr187) Antibody (YA455)
COX2 Antibody
ERK2 Antibody
COX IV Antibody
COX2/Cyclooxygenase 2 Antibody
ERK5 Antibody
ERK1 Antibody
KGF Antibody
Phospho-ERK1/2 (Thr202/Thr185) Antibody
Phospho-ERK1/2 (Tyr204/Tyr187) Antibody
COX IV Antibody (YA867)
CTGF Antibody
phospho-ERK1 + 2 (Thr183/Tyr185) Antibody
FAP Antibody (YA1090)
Cyclooxygenase 1 Antibody (YA2537)
Cyclooxygenase 2 Antibody (YA2541)
Folate Binding Protein Antibody (YA1099)
FRS2 Antibody (YA1400)
MC4R Antibody (YA1645)
Frizzled 9 Antibody (YA1930)
MC1R Antibody (YA2019)
Frizzled 8 Antibody (YA2052)
Glutathione Peroxidase 2 Antibody (YA2153)
FIG4 Antibody (YA2516)
Fetal Hemoglobin Antibody (YA2564)
FHIT Antibody (YA2677)
ELK1 Antibody (YA2758)
Fetuin A Antibody (YA2824)
分子量：288.22
Formula：C913C6H15NaO4
非标记 CAS：29679-58-1
中文名称：菲诺洛芬-13C6
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (534 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
 [Content Brief]
[2]. Montero-Melendez T, et al. Old drugs with new skills: fenoprofen as an allosteric enhancer at melanocortin receptor 3. Cell Mol Life Sci. 2017 Apr;74(7):1335-1345.
 [Content Brief]
[3]. Xiao-Chen Yuan, et al. Fenoprofen-An Old Drug Rediscovered as a Biased Allosteric Enhancer for Melanocortin Receptors. ACS Chem Neurosci. 2019 Mar 20;10(3):1066-1074.
 [Content Brief]